Altered skin microbiome in prurigo nodularis

#Altered #skin #microbiome #prurigo #nodularis

The microbiome in prurigo nodularis lesions is altered compared to healthy skin. Whether this is a result or a cause of the disease remains unclear.

Towfiqu Barbhuiya/AdobeStock

Prurigo nodularis (PN) is a chronic disease characterized by multiple, symmetrically distributed nodular lesions that occur primarily on the arms, legs and trunk and are accompanied by intense itching. The quality of life of those affected is significantly reduced. PN is associated with many other diseases such as anxiety, depression, but also systemic diseases such as Hashimoto’s, diabetes mellitus types 1 and 2, non-Hodgkin’s and Hodgkin’s lymphomas and much more. Around 65 – 80% of those affected also suffer from atopic dermatitis (AD).

Previous studies have already established a connection between PN and various infectious factors, but concrete data on the direct presence of microorganisms in the lesions are lacking. The present study aims to evaluate the diversity and composition of the bacterial microbiome in PN lesions and to gain a better understanding of the possible role of the microbiome in the pathogenesis of the disease. It was hypothesized that complex relationships between microorganisms could influence the perception of itch and thus contribute to the development of PN.

To view the content you must log in or register.