good news!! 95% of the COVID-19 outbreaks around the world are still the JN.1 omicron subtype.

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The Genome Center says good news for 95% of the COVID-19 outbreak currently circulating around the world. It is still an Omicron subspecies, group JN.1, but new mutations still need to be watched.

Medical Genome Center, Ramathibodi Hospital, posted on its Facebook page. Center for Medical Genomics Good news: 95% of the COVID-19 outbreak currently circulating around the world is of the JN.1 subspecies of Omicron, stating that

From the report on the mutation situation of the Covid virus on March 4, 2024, it was found that from the genetic decoding of the Covid virus collected around the world in February 2024, the Omicron subspecies group JN.1, including hybrid strains between the JN.1 group and the Mild symptoms

However, it was found that omicrons in the JN.1 group began to have mutations in the spike protein at 3 additional positions, namely R346T, F456L, and T572I, which may increase their ability to spread. But the severity of the infection cannot yet be assessed.

Currently, approximately 281 cases of mutations in all three loci in Omicron JN.1 have been found worldwide, and more are expected to be found in the coming months.

Omicron JN.1 with the R346T, F456L, and T572I mutations has a 20-35% weekly spread advantage over normal Omicron JN.1. These mutations may make the virus easier to spread. and can evade some immunity Including it may occur in different forms. As a result, various subspecies of Omicron JN.1 There are different properties available.

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Currently, there is no other family of Omicrons that can compete with the BA.2.86 family, which is the progenitor of the JN.1 Omicrons. It is expected that in the coming months, the JN.1 Omicrons will continue to be the main family of Omicrons. Continuously spreading This eases concerns about the severity of the COVID-19 disease. But if mutations occur in leaps and bounds, the situation may change.

Although the rate of omicrons with three mutations (R346T, F456L, and T572I) is doubling every week, it is expected that it will take another few months for these omicrons to become available. will become the dominant species. Because at present there are still very few cases found, only 281 from random tests around the world. and has not yet been found in many countries, including Thailand

In summary, group JN.1 omicrons are likely to remain the most common species in the coming months. But important sub-mutations such as R346T, F456L and T572I must be monitored, as well as the rapid emergence of new strains. To be able to assess risks and plan responses in a timely manner.

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