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Genetic Factor Influences opioid Response, Study finds
A new study led by researchers at the University of Calgary has identified a genetic variation that may explain why some individuals experience notable pain relief from opioid medications, while others find them ineffective or suffer adverse effects. The research, published in the journal Neuron, centers on the RUNX1 gene and its impact on opioid response, including pain reduction, dosage requirements, and the risk of withdrawal and dependence.
The Role of the RUNX1 Gene
The study revealed that variations within the RUNX1 gene are linked too differing responses to opioids. RUNX1 is a gene crucial for the growth and function of various tissues,including the brain. Researchers found that specific variants of this gene correlated with a need for higher opioid dosages, while others were associated with more severe withdrawal symptoms [[1]].
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