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The depression is a known risk factor for cardiovascular disease (CVD)However, possible sex differences in this association are still unclear.
The objective of this study, led by Keitaro Senoo of the Department of Cardiac Arrhythmia Research and Innovation at Kyoto Prefectural University of Medicine in Japan, was to investigate the relationship between depression and cardiovascular events later, and explore possible differences between men and women.
They performed a retrospective analysis using the JMDC epidemiological receipts database. The study population included 4,125,720 people aged 18 to 75 years with no history of CVD or kidney failure. Participants were followed for an average of 1,288 days to evaluate the association between mental disorder and subsequent cardiovascular events, such as myocardial infarction, angina pectoris, cerebrovascular accident, heart failure y atrial fibrillation.
A significant association was observed between depression and composite cardiovascular events in both men and women, with this being more evident in women. The hazard ratio (HR) for the composite endpoint was 1.64 (95% CI, 1.59-1.70) in women and 1.39 (95% CI, 1.35-1.42) in women. ) in men. In the same way, the individual components were related to the mental disorder in both sexes, and it was also evident that each of these had a stronger link in women.
The findings suggest that there is a significant association between depression and subsequent cardiovascular events in both men and women, with this being more pronounced in women. This highlights the importance of addressing the Mental illness and adapt prevention and management strategies according to sex-specific factors.
Bibliographic source
Sex Differences in the Association Between Depression and Incident Cardiovascular Disease
Senoo K, et al. Department of Cardiac Arrhythmia Research and Innovation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
JACC: Asia. 2024; 4(4):279–288
