On Wednesday, April 22, 2026, the Miami Marlins will face the St. Louis Cardinals in a National League matchup at LoanDepot Park in Miami, Florida. The game is scheduled to begin at 6:40 PM Eastern Time, continuing a three-game series between the two clubs. Both teams enter the contest with similar records, as the Marlins hold an 11-12 mark while the Cardinals stand at 13-9 through the first month of the 2026 MLB season.
This matchup follows the Marlins’ 5-3 victory over the Cardinals on April 20, where Agustín Ramírez hit a two-run home run and Max Meyer pitched effectively into the sixth inning to snap St. Louis’ five-game winning streak. The Cardinals had entered that game riding momentum from a series of wins but were held to just three runs off Marlins pitching, with reliever Carlos Faucher earning the win and Paul Fairbanks recording the save.
According to MLB’s official schedule and standings as of April 21, 2026, the Cardinals lead the National League Central division while the Marlins are positioned in the National League East. The teams last met during spring training in March, splitting their exhibition games ahead of the regular season opener.
For this Wednesday’s contest, St. Louis is expected to start right-hander Miles Mikolas, who carries a 2-1 record and 3.28 ERA through his first four starts of the season. Mikolas has struck out 24 batters in 24.2 innings while walking only six. Miami will counter with left-hander Braxton Garrett, who is 1-2 with a 4.15 ERA and has recorded 18 strikeouts in 21.2 innings pitched.
Offensively, the Cardinals have been led by first baseman Nolan Arenado, who is batting .298 with four home runs and 18 RBIs, and shortstop Masyn Winn, who is hitting .275 with three steals. The Marlins receive consistent production from second baseman Xavier Edwards, batting .287 with 12 RBIs, and center fielder Victor Victor Mesa II, who is hitting .263 with eight stolen bases.
Defensively, St. Louis ranks seventh in the National League in fielding percentage at .985, while Miami ranks 10th at .982. Both teams have committed 14 errors through 23 games, with the Cardinals turning 28 double plays compared to the Marlins’ 24.
Weather conditions in Miami for game time are forecast to be partly cloudy with a temperature of 82°F and humidity at 65%, with light winds coming in from left field at 5-10 mph. These conditions typically favor neither pitchers nor hitters significantly at LoanDepot Park, which plays neutrally for both batted ball types and pitching performance.
The winner of this game will take the season series lead between the two clubs, with each team having won one game so far in their 2026 meetings. A Marlins victory would even the spring and early season head-to-head record at one win apiece, while a Cardinals win would give them their first series victory over Miami this year.
Fans can watch the game live on MLB.TV or through local broadcast affiliates, with coverage beginning 30 minutes prior to first pitch. Post-game analysis and highlights will be available on MLB.com and team-affiliated platforms following the conclusion of play.